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Extra resources for Uncertainties in the Estimation of Radiation Risks and Probability of Disease Causation
2 Sources of Epidemiological Uncertainties A variety of epidemiological characteristics of studies pertaining to the adequacy of the study design, methods and basic epidemiological features need to be considered, to characterize and, ideally, to estimate the magnitude of uncertainty and bias associated with them. While the greatest concern is the potential of these methodological features to introduce systematic uncertainty or bias, it is important to note that these features will induce bias on 30 / 2.
If the associated doses or dose coefficients are treated as fixed, they may introduce biases into the risk estimates without account being taken of the uncertainty associated with those assignments, so modeling shared errors is an attempt to include uncertainties about the accuracy of values assigned to groups of study members. The purpose of accounting for a shared uncertainty in dose reconstruction is to add 26 / 2. UNCERTAINTIES IN EPIDEMIOLOGICAL STUDIES a component to the variance that reflects uncertainty about the bias potential.
2007). If the missed dose is uncorrelated with the doses of interest, it may nevertheless be a source of “noise” in the doseresponse assessment, in that some people may have much more medical exposure than others, and this noise may decrease the precision of the dose-response-based risk estimate for the radiation source of interest. 5 Survivor Bias. , people with that disease or related conditions may have died disproportionately) so that those alive at the time of the cross-sectional study may provide a biased sample of outcomes.
Uncertainties in the Estimation of Radiation Risks and Probability of Disease Causation by Ncrp Publications