By Germany) Symposium on 3-D Radiation Treatment: Technological Innovations and Clinical Results (1999

ISBN-10: 3805569475

ISBN-13: 9783805569477

Radiation treatment is within the strategy of continuous swap, fueled through advances in desktop know-how, but in addition aided by means of the contributions of a number of disciplines similar to physics, arithmetic, radiological diagnostics, neurosurgery, and mechanical and electric engineering. according to the 3D imaging concepts CT and MRI, a whole swap from the second attention of the radiotherapy challenge has taken position, resulting in 3D therapy making plans and to totally new remedy supply structures. A 3D technique allows a dramatic rethinking of the next valuable remedy concerns: positioning, concentrating on, and dose and hazard calculation. significant advances were made in recent times in conformal or stereotactic strategies, in dosimetry, the objective quantity notion in addition to scientific reviews. The advances are mirrored within the papers accumulated right here from the foreign symposium '3D Radiation remedy: Technological recommendations and medical effects' held in Munich in March 1999.

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The effect of EGF was receptor density dependent as the degree of EGF radiosensitization was inversely related to the number of high-affinity EGFRs [13]. Another study showed that the radiosensitizing effect of EGF was more pronounced if the cells were intrinsically more radiosensitive [15]. Addition of TGF- , another member of EGF family, enhanced radiosensitivity of MCF-7 cells by downregulation of estrogen receptors [18]. EGF was also reported to protect cells against radiation killing [16, 17].

Linac-Implemented Multi-Leaf Collimators In the early 90s, the companies involved in the development of linacs came up with computer-controlled MLCs integrated into the irradiation head of the accelerator. g. dosimetry of MLCs, verification of leaf positioning, interfacing with the treatment-planning program, and quality assurance turned out to be non-trivial difficulties. Today, most of these problems have been solved and the MLCs are being used in clinical practice, mainly with the purpose of replacing blocks for the creation of irregular-shaped fields.

Table 2 shows the dose-volume data for the normal brain and indicates that the volume of normal brain exposed to high doses is substantially reduced. From these data it appears that the IMRT dose distributions are more conformal than arcs. Part of the difficulty of obtaining adequate dose distributions when more than one set of arcs is employed is that each arc contributes dose to the region Intensity-Modulated Stereotactic Radiosurgery 47 treated by other arcs. For this reason conformal arcs may not be able to produce as good dose distributions for multiple foci as they do for a single tumor.

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Three-Dimensional Radiation Treatment: Technological Innovations and Clinical Results Symposium on 3-D Radiation Treatment: Technological Innovations and ... of Radiation Therapy and Oncology) by Germany) Symposium on 3-D Radiation Treatment: Technological Innovations and Clinical Results (1999


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