By Craig W. Ritchie, Visit Amazon's David Ames Page, search results, Learn about Author Central, David Ames, , Colin L. Masters, Jeffrey Cummings

Commonly stated as probably the most demanding points of facing an growing old inhabitants, the expanding occurrence of cognitive decline within the aged provides the clinician with numerous complicated healing difficulties. Alzheimer's affliction and different dementias differ of their onset and development, as do sufferers of their responsiveness to remedy. Social administration is as very important because the selection of healing agent, and imposing potent and sympathetic remedy calls for care and sensitivity in addition to a valid wisdom of presently to be had suggestions. during this vital new paintings, top specialists evaluate the healing brokers at the moment on hand and examine their effectiveness. additionally integrated is an replace on fresh and on-going medical trials, the clients for brand new healing objectives and the advance of latest biomarkers that would relief popularity of sickness and therefore past intervention.

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This is an unusual choice for the MMSE range and would actually suggest that some of the patients recruited to the study would have had severe AD and the use of the drugs would therefore be technically outside the licensed indication. Patients who had previously received either galantamine or donepezil were excluded from the study. Randomization was stratified based on the baseline ADL scale score (the DAD). A cut-off point of 31 was chosen although no justification for this cut-off is included in the publication.

DONEPEZIL VS. RIVASTIGMINE: 12-WEEK STUDY [6] The first published head-to-head study was a 12-week multinational comparison assessing the tolerability, compliance and cognitive effects of the recommended doses of donepezil (up to 10 mg once daily) and rivastigmine (up to 6 mg twice daily). Patients who had previously received either drug were excluded. Patients receiving donepezil commenced on 5 mg tablets once daily for 28 days and then 10 mg tablets once daily. 1 25 Satisfaction/ease of use questionnaires Physician satisfaction/ease of use questionnaire* 1.

Patients who had been treated previously with cholinesterase inhibitors were excluded. Fourteen centres in the UK, Finland, Germany and Norway recruited 120 patients randomized in a 1:1 ratio stratified for disease severity (into mild MMSE scores of 19–24 inclusive, or moderate MMSE scores of 10–18 inclusive). Sixty-four patients received donepezil and 56 galantamine. The drugs were given orally and titrated to the maximum recommended dose according to the respective approved product labelling.

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Therapeutic Strategies in Dementia by Craig W. Ritchie, Visit Amazon's David Ames Page, search results, Learn about Author Central, David Ames, , Colin L. Masters, Jeffrey Cummings

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