By Stephan Beck, Alexander Olek

ISBN-10: 0471351261

ISBN-13: 9780471351269

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ISBN-13: 9783527304882

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This is often the 1st ebook that describes the function of the Epigenome (cytosine methylation) within the interaction among nature and nurture. It focuses and stimulates curiosity in what is going to be essentially the most intriguing parts of post-sequencing genome technology: the connection among genetics and the surroundings.
Written via the main respected authors within the box, this ebook is vital analyzing for researchers attracted to the technological know-how coming up from the human genome series and its implications on health and wellbeing care, and society

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Extra info for The epigenome : molecular hide and seek

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DNA hypomethylation, or loss of methylation, is also observed in many cancers and takes place in DNA regions containing repeat sequences [7]. Abnormal DNA methylation has a profound effect on the development of cancer. These important findings lay the groundwork for further development of technologies to analyze complex patterns of DNA methylation present in cancer genomes. 2 Restriction Landmark Genomic Scanning (RLGS) The concept of screening DNA methylation throughout the entire genome becomes increasingly relevant as the Human Genome Project is nearing completion.

Methylation of integrated adenovirus type 12 DNA sequences in transformed cells is inversely correlated with viral gene expression, Proc. Natl. Acad. Sci. USA 77, 253±256, 1980. ; Tjia, S. , The initiation of de novo methylation of foreign DNA integrated into a mammalian genome is not exclusively targeted by nucleotide sequence, J. Virol. 69, 1226± 1242, 1995. , Intraperitoneal dissemination of Ad12-induced primitive neuroectodermal hamster tumors: De novo methylation and transcription patterns of integrated viral and cellular genes, Under revision, 2002.

Hoppe-Seyler 372, 557±564, 1991. , DNA methylation profiles in the human genes for tumor necrosis factors a and b in subpopulations of leukocytes and in leukemias, Proc. Natl. Acad. Sci. USA 88, 5759±5763, 1991. , DNA methylation and gene activity, Annu. Rev. Biochem. 52, 93±124, 1983. , DNA methylation in early development, Human Molecular Genetics 4, 1751±1755, 1995. , A new concept in (adenoviral) oncogenesis: integration of foreign DNA and its consequences, BBA Rev. Cancer Res. 1288, 243±244, 1996.

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The epigenome : molecular hide and seek by Stephan Beck, Alexander Olek

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