By Abdelhamid H. Elgazzar
This Synopsis of Nuclear medication Pathophysiology arose from the popularity that there's a desire for a compact, readable account of this complicated and demanding topic. The ebook concisely describes proper anatomic and physiologic issues for every organ process and the pathophysiologic positive aspects of alternative appropriate illnesses and relates them to the scintigraphy of every method. It thereby presents an informative synopsis of the pathophysiologic foundation of nuclear drugs and molecular imaging. the quantity will function a short reference that would support the reader to appreciate assorted diagnostic scintigraphic styles and to pick acceptable therapy modalities in accordance with sensible imaging. it is going to turn out priceless to undergraduates and postgraduates in addition to to practitioners in medical and learn fields.
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Additional resources for Synopsis of Pathophysiology in Nuclear Medicine
For example, the concentration of Na+ ions in the extracellular fluid is ten times more than the concentration of Na+ ions in the cytoplasm, while the converse is true with K+ ions. In active transport, the transporters are very specific for a solute and exhibit saturation kinetics. In addition, the carrier protein imparts energy to the solute to move against electrochemical or concentration gradient. 8 Transport Through the Cell Membrane 23 transported molecule a carrier protein channel protein lipid bilayer electrochemical gradient EN ER Simple diffusion GY channelcarriermediated mediated diffusion diffusion PASSIVE TRANSPORT (FACILITATED DIFFUSION) b + ++ + + ACTIVE TRANSPORT ++ + membrane polarized + + closed + + + + + + + inactivated + membrane depolarized open Fig.
Physicochemical adsorption 111 In- and 99mTc-leukocytes, 111In-platelets 4. Cellular migration 5. Cell sequestration Heat-denatured 99mTc-RBC 6. Simple diffusion Diffusion and mitochondrial binding 133Xe, 81mKr, 99mTc-pertechnegas 99m Tc-sestamibi and tetrofosmin Diffusion and intracellular binding 99m Tc-Ceretec and Neurolite Diffusion and increased capillary permeability 67 Ga-citrate 7. Facilitated diffusion and transport, protein upregulation 8. Active transport [18F]-FDG, radiolabeled amino acids Radioiodide, 99mTcO4–, 201Tl thallous cation [18F]-FDG, radiolabeled amino acids 201 Tl thallous cation Na+/K+ ATPase pump 99m Tc-colloids in RES and lymph nodes 9.
The solute molecules in the extracellular fluid or in the cytoplasm can diffuse across the plasma membrane. Diffusion through the cell membrane is divided into two separate subtypes known as simple diffusion and facilitated diffusion (Fig. 6a). Simple diffusion can occur through the cell membrane, either through the intermolecular interstices of the lipid bilayer or through transport proteins (watery channels). Facilitated diffusion (carrier-mediated diffusion) involves translocating a solute through a cell membrane down its concentration gradient as in the case of simple diffusion, without expenditure of metabolic energy.
Synopsis of Pathophysiology in Nuclear Medicine by Abdelhamid H. Elgazzar