By Marek Prochazka

ISBN-10: 3319239902

ISBN-13: 9783319239903

This e-book offers an summary of contemporary advancements in RS and SERS for sensing and biosensing contemplating additionally obstacles, percentages and clients of this method. Raman scattering (RS) is a regularly occurring vibrational procedure delivering hugely particular molecular spectral styles. A critical challenge for the appliance of this spectroscopic procedure lies within the low pass portion of RS. Surface-enhanced Raman scattering (SERS) spectroscopy overcomes this challenge through 6-11 orders of importance enhancement in comparison with the traditional RS for molecules within the shut area of yes tough steel surfaces. hence, SERS combines molecular fingerprint specificity with capability single-molecule sensitivity. because of the contemporary improvement of latest SERS-active substrates, labeling and derivatization chemistry in addition to new instrumentations, SERS turned a truly promising instrument for lots of diverse purposes, together with bioanalytical reviews and sensing. either intrinsic and extrinsic SERS biosensing schemes were hired to observe and establish small molecules, nucleic acids and proteins, and in addition for mobile and in vivo sensing.

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Additional info for Surface-Enhanced Raman Spectroscopy: Bioanalytical, Biomolecular and Medical Applications

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Removing of a PS mask gives a periodical nanostructure array. In 1995, Hulteen and Van Duyne (1995) reported the preparation of periodic Ag triangle arrays with areas of 4–25 µm2 using double layer PS sphere mask. 3. Electrochemical deposition of metal followed by removal of PS mask leaves nanostructured film containing a regular hexagonal array of metallic nanoislands, nanoholes or nanovoids depending on the thickness of the deposited film (Abdelsalam et al. 2005). NSL is now recognized as a simple, inexpensive and repeatable nanofabrication technique used to produce highly ordered nanostructures with diverse functionalities (Zhang et al.

3 Scheme of basic configurations of a typical Raman experiment: a 90° scattering geometry for macroscopic samples, b 180° scattering geometry for microscopic samples using an optical microscope. GF grey filters, IF interference filter, NF notch filter samples and in Raman spectrometers equipped with an optical microscope. The beam splitter is used to switch between white light image of the sample and Raman measurement. A sample can be magnified by an objective and imaged by a video CCD camera. The microscope can be set up confocally.

Moreover, the distribution of LSPR of NPs aggregates of different sizes and shapes is strongly inhomogeneous which causes poor reproducibility of SERS enhancements (Wentrup-Byrne et al. 1993). 2 NPs and Nanostructures on Planar Supports Prepared by Bottom-Up Techniques Stability and spectral reproducibility of metallic NPs can be significantly improved if rationally designed NPs are self-assembled or immobilized on planar solid supports. In colloidal science, such an approach is commonly called a bottom-up technique.

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Surface-Enhanced Raman Spectroscopy: Bioanalytical, Biomolecular and Medical Applications by Marek Prochazka


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