By Fuyuhiko Tamanoi, Michael N Hall
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Additional info for Structure, Function and Regulation of TOR complexes from Yeasts to Mammals: Part B
MANNING correlated with electrophoretic mobility shifts of TSC1 and TSC2, suggestive of phosphorylation. However, whether this apparent phosphorylation was the direct effect of CDK4/6–cyclin D activity and, if so, what the relevant sites are remains unknown. It will be important to determine whether endogenous CDK–cyclin complexes phosphorylate TSC1 or TSC2 at the G1/S transition and whether this affects the role of mTORC1 in promoting cell cycle entry. The TSC1–TSC2 complex has also been reported to be regulated by the CDK1–cyclin B complex which controls progression through mitosis [103, 104].
J Cell Biol 173:279–289. 88. D. (2009). Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway. PLoS ONE 4:e6189. 89. , and Pan, D. (2004). Tsc2 is not a critical target of Akt during normal Drosophila development. Genes Dev 18:2479–2484. 90. A. (2009). Akt phosphorylates both Tsc1 and Tsc2 in Drosophila, but neither phosphorylation is required for normal animal growth. PLoS ONE 4:e6305. 91. , et al. (2002). Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin.
71. , and Tamanoi, F. (2008). The Tsc/Rheb signaling pathway controls basic amino acid uptake via the Cat1 permease in fission yeast. Mol Genet Genomics 279:441–450. 72. , and Tamanoi, F. (2004). The Rheb family of GTP-binding proteins. Cell Signal 16:1105–1112. 73. , and Tamanoi, F. (2001). Failure to farnesylate Rheb protein contributes to the enrichment of G0/G1 phase cells in the Schizosaccharomyces pombe farnesyltransferase mutant. Mol Microbiol 41:1339–1347. 74. M. (2005). Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.
Structure, Function and Regulation of TOR complexes from Yeasts to Mammals: Part B by Fuyuhiko Tamanoi, Michael N Hall