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T-cell neoplasia can be induced in the mouse by retrovirus integration in the vicinity of Myc, at a site called Pvt-1 (Graham 35 Table 2. Rat oncogenes and common MoMuLV integration sites, and comparative mapping. Locus RNO MMU HSA HRAS1 HRAS2 I(LGI) X 7 llpter-15 Xpter-q28 KRAS2 4 6 12pl2 ERBAI ERBBI NEU(ERBB2) 15 14 10 11 11 17qll-21 7p14-12 17q21 MYC MYCL MYCN 7 5 6 15 8q24 Ip 2p23-24 MLVIl MLVI2 MLVI3 MISI 7 2 15 7 15 15 5p14 15(Pvt-l) 8q24 Table 3. Rat genes: miscellaneous, and comparative mapping.

Mol Cell BioI 6: 1834-1837 Wiener F, Babonits M, Spira J, Klein G, Bazin H (1982) Nonrandom chromosomal changes involving chromosomes 6 and 7 in spontaneous rat immunocytomas. Internat J Cancer 29: 431-437 Yoshida MC (1978) Rat gene mapping by rat-mouse somatic cell hybridization and a comparative Q-banding analysis between rat and mouse chromosomes. H. H. Reiner The following map shows the chromosomal location of genes that have been mapped in both mouse and man. The chromosomal location of the homologous gene in man is indicated after each mouse gene.

Trends Genet 1:219-220 Brown SDM, Dover GA (1980) Conservation of segmental variants of satallite DNA of Mus musculus in a related species: Mus spretus. Nature 285:47-49 Bucan M. Yang-Feng T. Colberg-Poley A, Wolgemuth DJ, Francke U. Lehrach H (1986) Genetic and cytogenetic localisation of the homeobox containing genes on mouse chromosome 6 and human chromosome 7. EMBO J 5:2899-2905 Chamberlain JS. Grant SG. Reeves AA. Mullins 1M, Stephenson DA, Hoffman EP. Monaco AP. Kunkel 1M, Caskey CT, Chapman VM (1987) Regional localization of the murine Duchenne muscular dystrophy gene on the mouse X chromosome.

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