By Arthur G. Steinberg and Alexander G. Bearn (Eds.)

ISBN-10: 1483167577

ISBN-13: 9781483167572

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Extra info for Progress in Medical Genetics. Volume 5

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H u m a n Genetics, R o m e , p . E . 5 5 . Excerpta Medica Foundation, N e w Y o r k . , and C. L . Conley. 1 9 6 4 . Rate of sickling of red cells during deoxygenation of blood from persons with various sickling disorders. Blood 2 4 : 2 5 - 4 8 . Chatterjea, J . B . 1 9 5 9 . Haemoglobinopathy posium. in India. In: Abnormal Jonxis, J . H . P. and Delafresnaye, J . F . , Eds. , pp. Haemoglobins. A Sym- O x f o r d : B l a c k w e l l Scientific Publi- 322-339. Chernoff, A . , V . Minnich, S. N a - N a k o r n , S.

The difference in structure 39 THE THALASSEMIAS between hemoglobin Lepore (Washington) and Lepore o i i a n d i a ) depends, therefore, in the site of the unequal crossing over. Frequent crossing over does occur in areas of chromosome duplication as at the Bar locus in Drosophila melanogaster. - and S-loci may increase the chances of nonhomologous crossing over. A similar situation has been observed in the human haptoglobin loci, unequal crossing over probably being responsible for the unequal length of the a-chains of human haptoglobin (Smithies, Connell and Dixon, 1962).

Eds. , pp. Haemoglobins. A Sym- O x f o r d : B l a c k w e l l Scientific Publi- 322-339. Chernoff, A . , V . Minnich, S. N a - N a k o r n , S. T u c h i n d a , C. Kashemsant, and R . R . ChernofT. 1 9 5 6 . Studies on hemoglobin E . I. T h e clinical, hematologic and genetic characteristics of the hemoglobin E syndromes. J . L a b . Clin. M e d . 4 7 : 4 5 5 - 4 8 9 . THE 51 THALASSEMIAS Choremis, C , B . Defaranas, Motulsky, G. P. Fessas, G . R . Fraser, C. K a t t a m i s , D . Loukopoulos, Stomatoyannopoulos, and L .

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