By Daniel L. Hartl

ISBN-10: 0878933069

ISBN-13: 9780878933068

This paintings supplies a presentation of concept and remark for college kids on the undergraduate and graduate point. It introduces the foundations of genetics and records which are proper to inhabitants stories, and examines the forces affecting genetic edition from the molecular to the organismic point. built-in through the ebook are descriptions of molecular and different equipment used to review average populations in addition to idea utilizing real information. purposes of the rules mentioned are illustrated through labored examples.

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Extra resources for Principles of Population Genetics

Example text

TTA|TTA|TTA …; (2) replace randomly some nucleotides in this stretch (generally, random insertions/deletions should also be taken into account). The resulting stretch can be defined as a sequence with hidden periodicities. The frequency of random replacements may be biased in the different sites of a repeat. For instance, if the random replacements occur only in the first and second positions, this would yield the patterns NNA|NNA|NNA…, where N is any nucleotide. The period p = 3 has proved to be typical of both genes and pseudogenes [34, 35].

Ortutay C, Vihinen M (2008) PseudoGeneQuest: service for identification of different pseudogene types in the human genome. BMC Bioinformatics 9:299 45. Khurana E, Lam HY, Cheng C, Carriero N, Cayting P, Gerstein MB (2010) Segmental duplications in the human genome reveal details of pseudogene formation. Nucleic Acids Res 38:6997–7007 46. Suyama M, Harrington E, Bork P, Torrents D (2006) Identification and analysis of genes and pseudogenes within duplicated regions in the human and mouse genomes.

Sechellia; (2) the yakuba complex, composed by D. teissieri (D.  santomea are the two other species in this complex); and (3) a complex represented by D. erecta and D. orena [76–79].  1. Alternative tree reconstruction methods implemented in the MEGA version 5 [67] yield identical topologies (data not shown).  1 is consistent with those derived from other genes as well as using entire genomes [80–84]. 1 Entropy Analysis Here we present the results of a comparative analysis of DNA sequences related to the functional gene Est-6 and the putative pseudogene ψEst-6 in four populations of Drosophila melanogaster (Zimbabwe, Spain, California, and Venezuela).

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Principles of Population Genetics by Daniel L. Hartl


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