By Charles F. George and David G. Shand (Eds.)
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Extra resources for Presystemic Drug Elimination
This may reflect a difference between the liver and the gastrointestinal tract in terms of the enzymes normally present and in the genetic control of their synthesis in the presence of inducing agents. A s discussed in Chapter 3 , for compounds to be metabolized by the cells of the intestinal mucosa normally they must be in the process of being absorbed into t h e bloodstream from the lumen of the gut. By contrast, drugs present in the systemic circulation may not be available to the enzymes of the intestinal mucosa and it is not surprising that the response of the intestine to enzyme inducers is influenced by the r o u t e by which they are administered.
R. 4-Methylcatechol a m e t a b o h t e of homoprotocatechuic acid. Experimentia, 2 3 , 493-494 (1967) 75 SCHELINE, R. R. T h e m c t a b o h s m of some aromatic aldehydes a n d alcohols by t h e rat intestinal microflora. Xenobiotica, 2, 227-236 (1972) 76 SCHELINE, R. R. Metabolism of foreign compounds by gastrointestinal microorgan isms. , LEWKONiA, R. M. and PRICE EVANS, D. A. M c t a b o l i s m of salicylazosul- fapyridine in healthy subjects a n d in patients with ulcerative colitis. , ANDREWS, R.
Acta Endocrinologica, 38, 5 9 - 7 2 (1961) lODODGSON, K. , SPENCER, B. and WYNN, c. H. Studics ou sulphatascs. 12. T h e aryl sulphatases of h u m a n tissues. Biochemical Journal, 62, 500-507 (1956) 11 DUTTON, G. J. and BURCHELL, B. N e w e r aspects of glucuronidation. In Progress in Drug Metabolism, Vol. 2, edited by J. W . Bridges and L. F . Chasseaud, 1 - 7 1 . L o n d o n , John Wiley a n d Sons (1977) 12 EMBDEN, G. a n d GLAESSNER, K. Ü b e r den O r t d e r Ätherschwefelsäurebildung im Tierkörper.
Presystemic Drug Elimination by Charles F. George and David G. Shand (Eds.)