By John H. Gillespie

ISBN-10: 0801857554

ISBN-13: 9780801857553

This concise advent bargains scholars and researchers an summary of the self-discipline that connects genetics and evolution. Addressing the theories in the back of inhabitants genetics and proper empirical proof, John Gillespie discusses genetic go with the flow, usual choice, nonrandom mating, quantitative genetics, and the evolutionary benefit of intercourse. First released to broad acclaim in 1998, this significant primer has been up-to-date to incorporate new sections on molecular evolution, genetic go with the flow, genetic load, the desk bound distribution, and two-locus dynamics. This booklet is fundamental for college kids operating in a laboratory environment or learning free-ranging populations.

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Extra resources for Population Genetics: A Concise Guide

Example text

Thus, you will frequently see 6 estimated for silent variation only. In thecase of ADH,this involves including only the 13 segregating sites with silent variation. 12 Estimate B for silent variation a t the ADH locus. The coalescent may be used to derive the probability that two alleles different by origin are different by state, g. The two alleles willbe different if a mutation occurred on the lineages leading from their common ancestor; otherwise they will be identical. As the lineages of the two alleles aretraced backward in time, either a coalescence or a mutation will occur first.

Although 9 is perfect for describing the average rate of decay of variability, it does not give a good feeling forthe underlying randomness of genetic drift. In fact, the equation N t =No (1- A) t could give the impression that the heterozygosity of any particular population decreases nonrandomly. 1 but plots heterozygosities rather than allele frequencies. monotonically. Rather, it jumps up and down, eventually hitting zero andstayingthere. 8 for a while, it is reasonable to start wondering exactly what Nt really is.

As all variation is ultimately lost, we know that eventually one allele will be the ancestor of all of the alleles in the population. As there are 2N alleles in the population, the chance that any particular one of them is the ancestor of all (once H = 0) is just 1/(2N). If there were, say, i copies of the A1 allele, then the chance that one of the i copies is the ancestor is i l ( 2 N ) . Equivalently, if the frequency of the A1 allele is p , then the probability that all alleles are ultimately A1 is p .

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Population Genetics: A Concise Guide by John H. Gillespie


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