By J M Behnke

ISBN-10: 0850664993

ISBN-13: 9780850664997

The themes of parasitism, parasite-induced pathology and appropriate host reaction are interrelated, but their interdependence is never preferred. This choice of reviews, illustrated by way of landmark experiments, emphasize this primary point of

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Download e-book for kindle: Parasites: Immunity And Pathology: The Consequences Of by J M Behnke

The subjects of parasitism, parasite-induced pathology and correct host reaction are interrelated, but their interdependence is never liked. This number of reviews, illustrated by means of landmark experiments, emphasize this primary point of

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Sample text

3). Among the fundamental differences are that Leishmania is an intracellular parasite and probably as a consequence T-cell mediated immune responses are far more important. The parasites undergo development in the insect (sandfly) vector to a promastigote stage and at that time a major surface protein of 62–65 000 mol. wt. appears in all species studied; it is significantly glycosylated and has hence been termed gp63. 2. Structure of the variant surface glycoprotein (VSG) of Trypanosoma brucei.

Similarly, vaccination of mice against Leishmania major, using the membrane glycolipid antigen LPG (see Chapter 2), generated protective immunity, but when a small glycolipid subcomponent of the intact molecule was separated and used alone, the treated animals developed more intense pathology (Mitchell and Handman, 1986). These are important issues to resolve before the implementation of vaccines in control programmes for human parasites in the tropics. Whereas standards for animal vaccines may be lower, an effective vaccine for human use would have to be free of all side effects, otherwise local people would have to be persuaded that the suffering they are being asked to endure is for the good in the long term.

1988), The biochemical and immunochemical characterisation of the 30 kilodalton surface antigen of Brugia pahangi, Molecular and Biochemical Parasitology, 27, 83–92. M. and Capron, A. (1986), Schistosoma mansoni shares a protective oligosaccharide epitope with freshwater and marine snails, Nature (London), 323, 443–5. E. J. (1985), How the trypanosome changes its coat, Scientific American, 252, 32–9. , Bouvier, J. and Bordier, C. (1986), The major surface protein of Leishmania promastigotes is a protease, Journal of Biological Chemistry, 261, 9078–101.

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Parasites: Immunity And Pathology: The Consequences Of Parasitic Infections In Mammals by J M Behnke

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