By Nagara Tamaki, Yuji Kuge

ISBN-10: 4431980733

ISBN-13: 9784431980735

Molecular imaging performs a massive function in drug discovery and complex scientific perform. A symposium of global leaders in drug learn and improvement, molecular imaging, and clinical remedy together with regenerative remedy and radiation remedy has ended in the ebook of this booklet. in response to the court cases of the symposium, many glorious principles and priceless discussions are brought that may consultant the reader towards new advances in photon detection and protein amendment in addition to new advancements in molecular imaging itself. either protein amendment and photon detection are rising applied sciences that pontificate the promise of leading edge recommendations for drug discovery and remedy. The book of those complaints is a well timed technique of sharing major event and data with many experts worldwide. This publication can be of significant worth to a large choice of researchers within the fields of drug improvement and molecular imaging applied sciences, resulting in built-in clinical treatment and growth in human health and wellbeing.

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A, adapted with permission from reference 43 Hypoxia Imaging for Radiation Guidance 13 In theory, hypoxia-specific PET radiotracers, specifically those with the 2nitroimidazole backbone, should accumulate only in areas of chronic hypoxia, at PO2 levels below 10 mmHg, and are more sensitive at severe hypoxic conditions than the microelectrode [44, 45]. By extrapolation, they should not reflect the fluctuation of acute hypoxia. However, a recent study by the group at Memorial Sloan Kettering Cancer Center suggested that this is not the case.

Based on these achievements, a prototype brain PET scanner was developed to demonstrate the high spatial resolution and quantitative imaging capability required in human imaging. The prototype brain PET scanner has a patient port diameter of 350 mm and an axial field of view of 250 mm without interplane septa. It consists of 18 detector units arranged around the patient port. Each detector unit has 22 detector boards arranged along an axial field of view. The detector board has cadmium telluride (CdTe) detectors on each side.

Lewis PJ, Salama A (1994) Uptake of fluorine-18-fluorodeoxyglucose in sarcoidosis. J Nucl Med 35: 1647–1649. 6. Ohtsuka T, Nomori H, Watanabe K et al (2005) False-positive findings on [18F]FDG-PET caused by non-neoplastic cellular elements after neoadjuvant chemoradiotherapy for nonsmall cell lung cancer. Jpn J Clin Oncol 35: 271–273. 7. Lorenzen J, de Wit M, Buchert R et al (1999) [Granulation tissue: pitfall in therapy control with F-18-FDG PET after chemotherapy]. Nuklearmedizin 38: 333–336. 8.

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Molecular Imaging for Integrated Medical Therapy and Drug Development by Nagara Tamaki, Yuji Kuge


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