By Farber J.M.

MIG (monokine precipitated by way of I FN7) is a non-ELR CXC chemokine ligand for CXCR3. a receptor expressed totally on T cells and NK cells. unlike similar chemokines, MIG features a lengthy C-terminal extension that's topic to inactivating proteolytic processing. MIG is prompted in a number cells together with macrophages, endothelial cells, and parenchymal cells, essentially based on IFN7. MIG is a che mo tactic issue for T cells, rather following T mobilephone activation, and has been proven to urge adhesion of activated T cells to endothelial cells. MIG's fundamental position in vivo is presumed to be within the recruitment of T cells and NK cells to inflammatory websites the place IFN7 is being made. MIG has additionally been chanced on to inhibit colony formation from hematopoietic progenitors in vitro and to inhibit tumor progress and angiogenesis in vivo.

Show description

Read Online or Download MIG PDF

Similar genetics books

Get A Troublesome Inheritance: Genes, Race and Human History PDF

Drawing on startling new proof from the human genome, an explosive new account of the genetic foundation of race and its function within the human tale

Fewer principles were extra poisonous or damaging than the belief of the organic fact of race, and with it the concept that people of other races are biologically diversified from each other. For this comprehensible cause, the belief has been banished from well mannered educational dialog. Arguing that race is greater than only a social build can get a student run out of city, or no less than off campus, on a rail. Human evolution, the consensus view insists, resulted in prehistory.

Inconveniently, as Nicholas Wade argues in a difficult Inheritance, the consensus view can't be correct. and in reality, we all know that populations have replaced long ago few thousand years—to be lactose tolerant, for instance, and to outlive at excessive altitudes. Race isn't a bright-line contrast; via definition it implies that the extra human populations are stored aside, the extra they evolve their very own targeted characteristics below the selective strain often called Darwinian evolution. for lots of millions of years, so much human populations stayed the place they have been and grew special, not only in outward visual appeal yet in deeper senses as well.

Wade, the longtime journalist masking genetic advances for the hot York occasions, attracts greatly at the paintings of scientists who've made the most important breakthroughs in setting up the truth of contemporary human evolution. the main provocative claims during this e-book contain the genetic foundation of human social conduct. What we would name middle-class social traits—thrift, docility, nonviolence—have been slowly yet absolutely inculcated genetically inside agrarian societies, Wade argues. those "values" evidently had a robust cultural part, yet Wade issues to proof that agrarian societies developed clear of hunter-gatherer societies in a few an important respects. additionally arguable are his findings in regards to the genetic foundation of qualities we go along with intelligence, akin to literacy and numeracy, in sure ethnic populations, together with the chinese language and Ashkenazi Jews.

Wade believes deeply within the primary equality of all human peoples. He additionally believes that technology is healthier served through pursuing the reality with out worry, and if his project to reach at a coherent summa of what the recent genetic technology does and doesn't let us know approximately race and human background leads immediately right into a minefield, then so be it. this can now not be the final word at the topic, however it will commence a strong and past due dialog.

Download PDF by for the National Academy of Sciences, Francisco J. Ayala,: Tempo and Mode in Evolution: Genetics and Paleontology 50

Considering that George Gaylord Simpson released pace and Mode in Evolution in 1944, discoveries in paleontology and genetics have abounded. This quantity brings jointly the findings and insights of cutting-edge major specialists within the research of evolution, together with Francisco J. Ayala, W. Ford Doolittle, and Stephen Jay Gould.

Get Cycloadditions in Bioorthogonal Chemistry PDF

The sequence subject matters in present Chemistry Collections provides serious studies from the magazine issues in present Chemistry prepared in topical volumes. The scope of insurance is all components of chemical technology together with the interfaces with comparable disciplines comparable to biology, medication and fabrics technology.

Additional info for MIG

Example text

5 (Nagai et al. , 1978b). The isoelectric points of the B transferases in serum and ovarian cyst fluids from group Band AB individuals were determined by isoelectric focusing (Topping and Watkins, 1975). The major peaks of activity from both sources focused within the pH range 9-10. Kishi et at.

Removal of fucose destroyed the activity with anti-HI serum but left the inhibitory activity for the other anti-I sera unimpaired (Fig. 5). Removal of the terminal l3-galactosyl residues destroyed the reactivity of the glycolipids with six of the anti-I reagents, but with the remaining four sera the activity was unchanged or only slightly diminished. Finally. 3) Gal-(1-4)-GlcNAc- /6) Gal-(I- 4)-GlcNAc-(1 .. Anti-I sera (2nd category) • Anti-I sera (1st category) ~ .. Anti-HI sera Fig. 5. Tentative structure of I-antigen complex proposed by Gardas (I976h).

It was suggested that two repeating I3-Gal(l~4)GIcNAc residues and I3-GIcNAc(l~3)Gal residues might be essential for the full expression of activity. The glycosphingolipid was obtained by removal of sialic acid from a ganglioside isolated from bovine erythrocytes but the structure is identical with that of the H2-glycolipid (Table V) isolated from human red cell membranes except for the additional fucose residue in the H-active compound. It is thus feasible to suppose that this incomplete chain occurs on the human erythrocyte surface.

Download PDF sample

MIG by Farber J.M.

by Jeff

Rated 4.57 of 5 – based on 11 votes