By Farber J.M.
MIG (monokine precipitated by way of I FN7) is a non-ELR CXC chemokine ligand for CXCR3. a receptor expressed totally on T cells and NK cells. unlike similar chemokines, MIG features a lengthy C-terminal extension that's topic to inactivating proteolytic processing. MIG is prompted in a number cells together with macrophages, endothelial cells, and parenchymal cells, essentially based on IFN7. MIG is a che mo tactic issue for T cells, rather following T mobilephone activation, and has been proven to urge adhesion of activated T cells to endothelial cells. MIG's fundamental position in vivo is presumed to be within the recruitment of T cells and NK cells to inflammatory websites the place IFN7 is being made. MIG has additionally been chanced on to inhibit colony formation from hematopoietic progenitors in vitro and to inhibit tumor progress and angiogenesis in vivo.
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5 (Nagai et al. , 1978b). The isoelectric points of the B transferases in serum and ovarian cyst fluids from group Band AB individuals were determined by isoelectric focusing (Topping and Watkins, 1975). The major peaks of activity from both sources focused within the pH range 9-10. Kishi et at.
Removal of fucose destroyed the activity with anti-HI serum but left the inhibitory activity for the other anti-I sera unimpaired (Fig. 5). Removal of the terminal l3-galactosyl residues destroyed the reactivity of the glycolipids with six of the anti-I reagents, but with the remaining four sera the activity was unchanged or only slightly diminished. Finally. 3) Gal-(1-4)-GlcNAc- /6) Gal-(I- 4)-GlcNAc-(1 .. Anti-I sera (2nd category) • Anti-I sera (1st category) ~ .. Anti-HI sera Fig. 5. Tentative structure of I-antigen complex proposed by Gardas (I976h).
It was suggested that two repeating I3-Gal(l~4)GIcNAc residues and I3-GIcNAc(l~3)Gal residues might be essential for the full expression of activity. The glycosphingolipid was obtained by removal of sialic acid from a ganglioside isolated from bovine erythrocytes but the structure is identical with that of the H2-glycolipid (Table V) isolated from human red cell membranes except for the additional fucose residue in the H-active compound. It is thus feasible to suppose that this incomplete chain occurs on the human erythrocyte surface.
MIG by Farber J.M.