By David Cooper

ISBN-10: 1859961517

ISBN-13: 9781859961513

The tale of our evolutionary prior is advised in our genome series. Human Gene Evolution bargains with the origins of human genes, describes their constitution, functionality, organization and expression. The textual content integrates our rising wisdom of chromosome and genome constitution, and discusses the character of the mutational mechanisms underlying evolutionary switch.

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These domains can be combined in modular fashion to generate an array of different transcription factors (Latchman, 1998; Tjian and Maniatis, 1994). It is the cis-acting DNA sequences within a gene promoter that allow transcription factors to be brought into close proximity so that they may either interact with each other in the transcriptional initiation complex or combine together in an enhancer complex. No one enhancer-binding protein can act on its own, rather it must act in concert with other enhancer-binding proteins.

Imprinting and imprinted genes. ’ This differential modification appears to be essential for normal mammalian development since parthenogenetic embryos (whether diploid paternal or diploid maternal) do not survive to term: in diploid maternal embryos, fetal development is normal but development of the extraembryonic membranes is abnormal. In 30 HUMAN GENE EVOLUTION diploid paternal embryos, it is the other way around (reviewed by Monk, 1988). Clearly, maternal and paternal chromosomes must differ epigenetically and in such a way that different developmental programmes are followed.

These domains can be combined in modular fashion to generate an array of different transcription factors (Latchman, 1998; Tjian and Maniatis, 1994). It is the cis-acting DNA sequences within a gene promoter that allow transcription factors to be brought into close proximity so that they may either interact with each other in the transcriptional initiation complex or combine together in an enhancer complex. No one enhancer-binding protein can act on its own, rather it must act in concert with other enhancer-binding proteins.

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Human Gene Evolution (Human Molecular Genetics) by David Cooper


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