By Tobacco Advisory Group of the Royal College of Physicians
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Additional info for Harm reduction in nicotine addiction: helping people who can't quit
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Thus, it is still not clear which nAChR subtype or subtypes contribute to tobacco dependence, but animal models suggest that nicotinic receptors containing α4 and β2 subunits are the most likely candidates. 102 Finally, it is important to emphasise that existing animal testing paradigms model, at best, only certain aspects of cigarette smoking. 9 Conclusions H Nicotine targets receptors whose natural function is to interact with the neurotransmitter acetylcholine (ACh). H By activating these nicotinic receptors, nicotine increases the firing rate of neurons and increases the release of various neurotransmitters.
Harm reduction in nicotine addiction: helping people who can't quit by Tobacco Advisory Group of the Royal College of Physicians