By Parakrama T. Chandrasoma, Tom R. DeMeester

ISBN-10: 0123694167

ISBN-13: 9780123694164

The expanding occurrence of esophageal adenocarcinoma has created a major curiosity and stimulus for learn during this zone. GERD brings jointly, for the 1st time, an unlimited volume of disparate literature and records the complete pathogenesis of reflux ailment in a single position. The booklet provides reflux carditis as a brand new diagnostic criterion of GERD and for the 1st time defines the dilated end-stage esophagus and the earliest microscopic section of GERD that's neglected by way of current diagnostic standards. GERD provides either scientific and pathological info and is intended for use as a finished reference for gastroenterologists, esophageal surgeons, and pathologists alike. *Outlines how gastroesophageal reflux factors mobile alterations within the esophagus*Brings jointly the pathogenesis of the ailment in a single resource and applies it towards medical treatment*Tom DeMeester is THE prime foreign professional on reflux disorder; Parakrama Chandrasoma is likely one of the prime pathologists within the area*Book includes nearly 350 illustrations*Ancillary website good points colour illustrations: www.chandrasoma.com

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Sample text

He gave detailed and extremely accurate descriptions of the s y m p t o m s of heartburn, dysphagia, and regurgitation. ' If this had been taken at face value it would have been difficult to explain, but more detailed questioning revealed that it was in fact regurgitation of mucus. The belief that mucus is 'clear bile' may be local to Yorkshire, but it is a point worthy of emphasis" (p. 21). In light of present knowledge about the frequency of duodeno-gastric reflux, it is likely that the patient's description of "vomiting of bile" was more accurate than Allison's interpretation.

The position of the cardia which Allison and Johnstone used synonymously with the gastroesophageal junction can be identified where the lumen widens again to form the sac of the herniated stomach" (p. 99). There is no doubt when reading this paper that Allison and Johnstone were convinced of two things: (a) the correct conclusion that the tubular structure distal to the squamocolumnar junction was esophagus and not a tubular stomach as defined by Barrett and (b) the incorrect conclusion that the lining was gastric mucosa.

By 1929~it was clear all was not well, for Chevalier Jackson claimed to have seen 88 cases in 4000 consecutive endoscopies, whereas Stewart and Hartfall (7) had found but 1 example in 10,000 consecutive autopsies. (p. " This diagram shows serrated mucosa extending into the esophagus, both continuous with the gastric mucosa and as islets in squamous epithelium. Allison called this "heterotopic gastric mucosa"; this is the first depiction in the literature of columnar-lined esophagus. Reproduced with permission from Allison PR.

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GERD: Reflux to Esophageal Adenocarcinoma by Parakrama T. Chandrasoma, Tom R. DeMeester


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