By Wobus A., Wobus U.

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During the catabolism reaction, XDH reduces NAD+ to NADH, while XO catalyses the reduction of O2 leading to a formation of O2•− and it also causes to H2O2 production (Harrison, 2002; Nishino, 1994). Its in agreement that XDH activity is converted to an oxidase that produces O2•−, and H2O2. This phenomana may occur reversibily by sulfhydryl oxidation (in oxidative conditions), or irreversibily by limited proteolysis (Fig. 2) (Della Corte and Stirpe, 1968; Stirpe and Della Corte, 1970). The latter occurs as a result of a decrease in the intracellular pH followed by Ca2+ influx and proteases activation.

Radi, 1996, Peroxynitritedependent tryptophan nitration: Chem Res Toxicol, v. 9, p. 390–396. , M. M. Brysk, H. Brysk, and S. K. Tyring, 1996, Regulation of inducible nitric oxide synthase mRNA levels by differentiation and cytokines in human keratinocytes: Biochem Biophys Res Commun, v. 220, p. 618–622. , A. Walz, and S. L. Kunkel, 1989, Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils: J Clin Invest, v. 84, p. 1045–1049. Beckman, J. , 1996, Oxidative damage and tyrosine nitration from peroxynitrite: Chem Res Toxicol, v.

A. Cohen, 2004, S-Glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide: Nat Med, v. 10, p. 1200–1207. , and G. Burnstock, 1998, Watanabe rabbits with heritable hypercholesterolaemia: a model of atherosclerosis: Histol Histopathol, v. 13, p. 797–817. , and R. Radi, 2003, Peroxynitrite reactivity with amino acids and proteins: Amino Acids, v. 25, p. 295–311. , H. Rubbo, M. Kirk, S. Barnes, B. A. Freeman, and R. Radi, 1996, Peroxynitritedependent tryptophan nitration: Chem Res Toxicol, v.

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Genetik, zwischen Furcht und Hoffnung by Wobus A., Wobus U.


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