By Joseph Panno

ISBN-10: 0816049483

ISBN-13: 9780816049486

ISBN-10: 0816067341

ISBN-13: 9780816067343

Gr. 9-12. The technology and expertise are designated, dense, actual, and updated during this name within the New Biology sequence, and the readable dialogue of the moral concerns indicates that there are not any easy solutions. Physiologist Panno explains how stem cells can be utilized to regard, and probably treatment, a large choice of ailments, and he predicts that using grownup stem cells will quickly be regimen. a big bankruptcy appears at felony practices within the united states, Europe, and the U.K. The e-book comprises occasional diagrams; an intensive, designated word list; and lots of bibliographical references to technological know-how and moral discussions in print and on the net. furthermore, there's a bankruptcy summarizing mobile biology and recombinant DNA know-how. a gently performed, in-depth sequence that may paintings good for researchers and debaters, adults in addition to adolescents. different titles during this new sequence: The phone, getting older, Animal Cloning, melanoma, and Gene remedy. Hazel Rochman Copyright © American Library organization.

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Additional info for Gene Therapy: Treating Disease by Repairing Genes (New Biology)

Example text

Yet, these masters of death and destruction are about to pay us back, in full and with interest. For without the viruses, there would be no gene therapy, and if we consider their ancestors, the plasmids, evolution of animal life on this planet would have been a much slower process. When we speak of curing someone of a genetic disease, we are referring to gene replacement, or the process of introducing a normal gene into a defective cell. But how is this to be done? Eukaryotes are a clever bunch, and they take a dim view of foreign genes dropping by for lunch.

But there are two major Viruses 29 problems to overcome before they can be used safely: First, the ability of the virus to replicate its own genome must be blocked, along with the production of viral mRNA that codes for proteins that maintain the infection and help the virus escape from the cell. Second, the therapeutic gene has to be inserted into the viral genome in such a way that it will not inhibit the formation of a normal capsid, since this is the part of the virus that is essential for cell entry.

Viral genes needed for replication and the maintenance of infection are removed, after which the therapeutic gene is inserted into the viral chromosome. The hybrid chromosome is added to a test tube and mixed with purified viral capsid proteins, leading to the auto-assembly of viral particles. If this is done properly, the virus will be able to enter the cell to deliver the gene, but it will not harm the cell, nor will it be able to reproduce itself. Viruses Used in Gene Therapy Adenovirus type 2 (AD-2) and a retrovirus called murine (mouse) leukemia virus (MuLV) have been used in more than 90 percent of all gene therapy trials to date.

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Gene Therapy: Treating Disease by Repairing Genes (New Biology) by Joseph Panno

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