By Ulrich Flogel, Eric Ahrens
Over the prior decade, fluorine (19F) magnetic resonance imaging (MRI) has garnered major medical curiosity within the biomedical examine neighborhood as a result of the original houses of fluorinated fabrics and the 19F nucleus. Fluorine has an intrinsically delicate nucleus for MRI. there's negligible endogenous 19F within the physique and therefore there's no history sign. Fluorine-containing compounds are perfect tracer labels for a large choice of MRI purposes. furthermore, the chemical shift and nuclear rest fee may be made attentive to body structure through inventive molecular layout.
This booklet is an interdisciplinary compendium that information state of the art technological know-how and scientific examine within the rising box of 19F MRI. Edited by way of Ulrich Flögel and Eric Ahrens, sought after MRI researchers, this publication will entice investigators all for MRI, biomedicine, immunology, pharmacology, probe chemistry, and imaging physics.
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Additional resources for Fluorine magnetic resonance imaging
MRI Hardware and Reconstruction for Simultaneous 19F/1H Imaging In vivo simultaneous 19F/1H imaging has been demonstrated using targeted PFC NP and the modified clinical 3 T as mentioned above. 3 illustrates combined 19F and 1H imaging with the use of av b3-integrin targeted nanoparticles for quantitative assessment of angiogenesis in a rabbit tumor model on the modified clinical 3 T scanner . 2 × 4 mm3 as visualized in the color overlay in Fig. 3b,d,e. A 3-D gradient echo sequence was used for 19F, and a 3-D T -weighted gradient echo sequence for the 1H 1 image acquisition was used to depict morphology (specifically, the popliteal fossa of the hind leg, Fig.
Magnetization transfer that enhances the 19F signal, and the homonuclear T1 relaxation that drives 19F signal towards equilibrium reach a balanced state. For measurements at 3 T, signal increases of 20% for fluorodeoxyglucose (FDG), 9% for 23 24 Pulse Sequence Considerations and Schemes trifluoroacetic acid and 12% for trifluoroethanol (TFE) were observed (shown for FDG in Fig. 11a). A single 1H saturation pulse caused smaller enhancement of 19F signal, peaking after approximately 2 s. The signal progression is shown for FDG in Fig.
Aime S, Carrera C, Delli Castelli D, Crich SG, Terreno E. (2005). Tunable imaging of cells labeled with MRI-PARACEST agents. Angew Chem Int Edit, 44, 1813–1815. Chalmers KH, Kenwright AM, Parker D, Blamire AM. (2011). 19F-lanthanide complexes with increased sensitivity for 19F-MRI: Optimization of the MR acquisition. Magn Reson Med, 66, 931–936. de Vries A, Moonen R, Yildirim M, Langereis S, Lamerichs R, Pikkemaat JA, Baroni S, Terreno E, Nicolay K, Strijkers GJ, Grull H. (2014). Relaxometric studies of gadolinium-functionalized perfluorocarbon nanoparticles for MR imaging.
Fluorine magnetic resonance imaging by Ulrich Flogel, Eric Ahrens