By Mark D. Bednarski and Ethan S. Simon (Eds.)

ISBN-10: 0841213224

ISBN-13: 9780841213227

ISBN-10: 0841220972

ISBN-13: 9780841220973

content material: Enzymes as catalysts in carbohydrate synthesis / Eric J. Toone and George M. Whitesides --
Microbial aldolases in carbohydrate synthesis / C.-H. Wong --
Use of glycosyltransferases in synthesis of unnatural oligosaccharide analogs / Ole Hindsgaul, Kanwal J. Kaur, Uday B. Gokhale, Geeta Srivastava, Gordon Alton, and Monica M. Palcic --
Use of glycosidases and glycosyltransferases within the synthesis of complicated oligosaccharides and their glycosides / K.G.I. Nilsson --
Glycosylation via use of glycohydrolases and glycosyltransferases in preparative scale / Peter Stangier and Joachim Thiem --
Use of glycosyltransferases for drug amendment / Daniel Gygax, Mario Hammel, Robert Schneider, Eric G. Berger, and Hiltrud Stierlin --
a few features of enzymic synthesis of oligosaccharides utilising acceptor saccharides hooked up to polymer companies / Uri Zehavi and Joachim Thiem --
Galactose oxidase : chosen homes and artificial purposes / Adam W. Mazur --
commercial program of adenosine 5'-triphosphate regeneration to synthesis of sugar phosphates / H. Nakajima, H. Kondo, R. Tsurutani, M. Dombou, I. Tomioka, and ok. Tomita.

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Extra info for Enzymes in Carbohydrate Synthesis

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26. 27. 28. 29. ENZYMES IN CARBOHYDRATE SYNTHESIS Berliner, L . ; Robinson, R. D . Biochemistry 1982, 21, 6340-6343. ; Grier, T . ; Rasmussen, J. ; Schwarz, R. T . Biochem. J. 1987, 248, 523-531. Gross, H . ; Bunsch, J. ; Paulson, J. ; Brossmer, R. Eur. J. Biochem. 1987, 168, 595-602. Shibaev, V . N . Pure Appl. Chem. 1978, 50, 1421-1436. Druzhinina, T . ; Gogilashvili, L . M . ; Shibaev, V . N . Bioorg. Khim. 1988, 14, 1242-1249. Palcic, M . M . ; Venot, A . ; Ratcliffe, R. ; Hindsgaul, O. Carbohvdr.

Schauer, R. Adv. Carbohydr. Chem. Biochem. 1982, 40, 131. The Lectins: Properties, Functions and Applications in Biology and Medicine; Liener, I. E . ; Goldstein, I. ; Academic: New York, 1986. Paulson, J. C. In The Receptors; Cohn, P. M . ; Academic: New York, 1985; Vol. 2, p 131. Sairam, M . R. In The Receptors; Cohn, P. M . ; Academic: New York, 1985; Vol. 2,p307. Rademacher, T. ; Parekh, R. ; Dwek, R. A . Ann. Rev. Biochem. 1988, 57, 785. Rice, G. ; Bevilacqua, M . P. Science 1989, 246, 1303.

We report here on our recent progress in using glycosyltransferases mainly in the preparation of deoxygenated oligosaccharides. Our particular emphasis on deoxygenated compounds, as opposed to halogenated or other analogs, stems from a wide body of literature demonstrating the utility of such compounds in probing the the molecular specificity of carbohydrate-protein recognition (15). The realization that deoxygenated analogs of glycosyltransferase acceptors can also serve as potent inhibitors for the enzymes (10 has further increased the potential use of such analogs.

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Enzymes in Carbohydrate Synthesis by Mark D. Bednarski and Ethan S. Simon (Eds.)


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