By Henry L. Foster, J. David Small, James G. Fox

ISBN-10: 0122625021

ISBN-13: 9780122625022

Ailments -- quantity II of The Mouse in Biomedical study. Compiles for the 1st time in a single layout a story detailing infectious illnesses of the mouse.

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Additional info for Diseases. The Mouse in Biomedical Research

Sample text

Chronically affected mice also s h o w e d inactivity, weight loss, r o u g h hair coats, and d y s p n e a . A mortality of 9 5 % was observed over a period of 11 m o n t h s ( N e l s o n , 1937a). In subsequent y e a r s . N e l s o n ( 1 9 5 5 , 1 9 6 3 , 1967a,b) c o n ­ tended that the erratic p n e u m o n i a o b s e r v e d in such cases w a s viral in origin. B e c a u s e of this belief, the p n e u m o n i a w a s first designated endemic pneumonia ( N e l s o n , 1955) and later en­ zootic bronchiectasis ( N e l s o n , 1963).

T h u s , there is a m p l e reason to believe that offspring of infected d a m s most c o m m o n l y acquire the infection by aerosol t r a n s m i s s i o n during the first few d a y s of life ( K l i e n e b e r g e r and N o b e l , 1962; L e m c k e , 1961). T r a n s p l a c e n t a l t r a n s m i s s i o n also a p p e a r s p o s ­ sible ( G a n a w a y et aL, 1973; J u h r et aL, 1970; T r a m et aL, 1970). D a t a c o n c e r n e d with survival of the o r g a n i s m outside the host, as in c o n t a m i n a t e d food and w a t e r , are contradictory (Juhr, 1 9 7 1 ; V o g e l z a n g , 1975).

A l s o , tissues m a y contain a g r o w t h inhibitor (Tully and R a s k - N i e l s e n , 1967), thought to be lysolecithin. Addition of lysophospholipase ( K a k l a m a n i s et aL, 1969; M a r d h and T a y l o r - R o b i n s o n , 1973) or serial dilution of tissue suspensions in broth (Tully and R a s k - N i e l s e n , 1967) abolishes this a n t i - m y c o p l a s m a l activity. M y c o p l a s m a s are m o r e difficult to g r o w on artificial m e d i a than most bacteria. In k e e p i n g with their small g e n o m e s i z e , m y c o p l a s m a s have a limited biosynthetic capacity and there­ fore require a wide array of precursor m o l e c u l e s for m a c r o m o l e c u l a r synthesis (Rodwell and M i t c h e l l , 1979).

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Diseases. The Mouse in Biomedical Research by Henry L. Foster, J. David Small, James G. Fox

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