By Lynn Arthur Steen, J. Arthur Seebach Jr.

ISBN-10: 048668735X

ISBN-13: 9780486687353

Over a hundred and forty examples, preceded by means of a succinct exposition of normal topology and easy terminology. every one instance taken care of as a complete. Over 25 Venn diagrams and charts summarize houses of the examples, whereas discussions of basic equipment of building and alter supply readers perception into developing counterexamples. contains difficulties and workouts, correlated with examples. Bibliography. 1978 version.

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Splicing of the intron downstream. Mol Cell Biol 17:4667–4676. Chan RC, Black DL (1997) Conserved intron elements repress splicing of a neuron-specific c-src exon in vitro. Mol Cell Biol 17:2970. Chan RC, Black DL (1995) Conserved intron elements repress splicing of a neuron-specific c-src exon in vitro. Mol Cell Biol 15:6377–6385. Xu R, Teng J, Cooper TA (1993) The cardiac troponin T alternative exon contains a novel purine-rich positive splicing element. Mol Cell Biol 13:3660–3674. Ryan KJ, Cooper TA (1996) Muscle-specific splicing enhancers regulate inclusion of the cardiac troponin T alternative exon in embryonic skeletal muscle.

Each gel element contains a specific oligonucleotide probe chemically bound to polyacrylamide. The 3D structure of the PAA gel-based elements allows immobilization of much greater amounts of the oligonucleotide probe within each element compared to 2D arrays, therefore increasing the intensity of the signal from an element. Hybridization and enzymatic reactions within the acrylamide gel more closely resemble liquid-phase reactions, rather than solid-phase reactions on 2D support. , determining the thermodynamic parameters of the nucleic acid duplexes (21) and de novo sequencing of short nucleic acids (22).

2 Alternative Pre-mRNA Splicing of G Protein-Coupled Receptors 21 splicing of GPCRs. Alternative splicing can lead to generating multiple protein ­products or isoforms from single gene. These protein products can encode truncated or novel proteins by losing segments of the protein or gaining new protein sequences, or changing the amino acid sequence through a reading-frame shifting or an early stop codon. Alternative splicing of GPCRs often leads to truncations at the N-terminus, C-terminus and transmembrane segments, or generation of new N-terminal and C-terminal sequences.

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Counterexamples in Topology, Second Edition by Lynn Arthur Steen, J. Arthur Seebach Jr.


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