By Cook, Gary J.R
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The advent of 3-D conformal radiation therapy has resulted in a need to identify the optimal spatial regions for boosting radiation dose. 40,75,76 In addition, the incorporation of PET/CT data directly into radiation treatment planning systems has been demonstrated to markedly improve the accuracy of radiation delivery to tumor (Fig. 13). This is an area of continued development and it is likely that PET/CT will have an increasingly important role in radiotherapy of malignancy in the future. A further application of imaging in treatment planning is in the conﬁrmation of dose delivery for locoregional treatment of tumors with chemotherapy and radiolabeled compounds.
This is an area of continued development and it is likely that PET/CT will have an increasingly important role in radiotherapy of malignancy in the future. A further application of imaging in treatment planning is in the conﬁrmation of dose delivery for locoregional treatment of tumors with chemotherapy and radiolabeled compounds. For example, the treatment of hepatic tumors (primary hepatocellular carcinoma or metastatic disease usually from colorectal cancer primary) with infusion of chemotherapy or radiolabeled spheres directly into the hepatic artery requires the conﬁrmation of the correct placement of vascular catheters prior to treatment (Fig.
Luciferase) can also be evaluated with this technique. This allows detection of cellular trafﬁcking in vivo, and assessment of therapeutic interventions, without radiation exposure. Recent developments in instrumentation have resulted in improvements in depth of ﬁeld and image resolution which have limited photonic detection techniques in the past. For optical imaging to fully realize its potential, further progress will be required in reﬁning optical detection methods and data acquisition techniques.
Clinical Nuclear Medicine Fourth Edition by Cook, Gary J.R