By Hyman M. Schipper

ISBN-10: 1570594899

ISBN-13: 9781570594892

256 pages, sixty seven figures, 6 tables, hardcover This monograph is the 1st of its type to concentration in particular at the position of astroglia in aging-related human neurodegenerative problems and experimental types of CNS senescence and degeneration. As such, this quantity within the Neuroscience Intelligence Unit sequence represents a singular and demanding contribution to the elemental and scientific neuroscience literature. The chapters are grouped into 3 sections: I. Biology of Astrocytes. The chapters during this part will represent a complete dialogue of the identified features of astroglia within the mammalian CNS and the jobs those cells might play within the pathophysiology of neurological issues. II. Astrocytes in Human mind Senescence and Neurodegenerative issues. during this part, the pathology of astrocytes and their putative roles in human CNS senescence and numerous neurodegenerative stipulations are coated in substantial aspect. III. Experimental versions of Astrocyte Senescence: Implications for Neurodegenerative ! affliction. during this ultimate part, experimental methods to the delineation of the function of astroglia in mind getting older and degeneration are defined. This publication should still allure extensively to easy neuroscientists drawn to numerous facets of the biology of those cells in addition to to clinically-oriented investigators focused on the pathogenesis of the foremost human neurodegenerative issues.

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Biophysical and pharmacological analysis of two Na+ current types. J Neurophysiol 1992; 68:1001-1011. 27. Black JA, Westenbroek R, Ransom BR et al. Type II sodium channels in spinal cord astrocytes in situ: Immunocytochemical observations. Glia 1994; 12:219-227. 28. Ritchie JM. Current perspectives in glial electrophysiology. Ann N Y Acad Sci 1991; 633:331-342. 29. MacVicar BA. Voltage-dependent calcium channels in glial cells. Science 1984; 2265: 1345-1347. 30. Verkhratsky A, Kettenmann H. Calcium signaling in glial cells.

Aoki and colleagues112,113 showed astrocytic localization of α2A and β-adrenergic and NMDA1 receptors to astrocytic profiles in visual cortex using electron microscopy with immunocytochemistry. 5HT1A,114 mGluR5,115 mGluR3,116 AMPA receptor subunits GluR1 and GluR4117 and muscarinic receptor118 immunoreactivities have also been localized to astrocytes in rat hippocampus. Paspalas and Papadopoulos119 have recently reported that fine norepinephrine-containing nerve terminals ended on astrocytes around capillaries in rat visual cortex, as well as directly on the basal lamina.

Gloor S, Antonicek H, Sweadner KJ et al. The adhesion molecule on glia (AMOG) is a homologue of the B subunit of the Na, K-ATPase. J Cell Biology 1990; 110:165-174. 52. Sontheimer H, Black JA, Ransom BR et al. Ion channels in spinal cord astrocytes in vitro. I. Transient expression of high levels of Na+ and K+ channels. J Neurophysiol 1992; 68:985-1000. 53. Boyarsky G, Ganz MB, Sterzel RB et al. pH regulation in single glomerular mesangial cells I. Acid extrusion in absence and presence of HCO3.

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Astrocytes in Brain Aging and Neurodegeneration by Hyman M. Schipper

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