By Greg Gibson

ISBN-10: 0878932364

ISBN-13: 9780878932368

Genome technology has matured as a self-discipline to the purpose the place it truly is now included as a standard a part of the genetics curriculum in universities. A Primer of Genome technological know-how, 3rd version bridges the space among ordinary genetics textbooks and hugely really good, technical, and complex remedies of the subdisciplines. It presents a reasonable and updated creation to the sector that's suited for complex undergraduate or early graduate classes. Bioinformatic rules and experimental ideas are defined side-by-side with the experimental tools, setting up a framework that permits academics to discover themes and the literature at their very own velocity. The Primer is prepared into six chapters facing the scope of genomics, genome sequencing, version and complicated qualities, gene expression, proteomics, and metabolomics. every one bankruptcy comprises a number of containers explaining the idea in the back of bioinformatic equipment, dialogue questions, and a precis. This version has been up-to-date to incorporate the most recent advancements in next-generation sequencing, high-volume genotyping and expression profiling, and advances in metabolomics.

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Extra resources for A Primer of Genome Science

Sample text

It is possible that an increase in gene number accompanied the evo­ lution of its largely invariant m ode of development. Some of the difference in gene number can be attributed to the expansion and contraction of par­ ticular gene families, such as the surprising surplus of steroid-hormone receptors in the nematode and the expansion of the olfactory receptor fam­ ily in Drosophila. In any case, it is clear that there is no simple relationship between gene number and tissue complexity—or for that matter, between gene number and DNA content.

Another goal is the education of self-help groups, educators, and the media about distin­ guishing between very complex statistical associations and oversimplified assertions about the nature-nurture debate, biological determinism, and heritability. Philosophical discussions cover issues ranging from the basis of human responsi­ bility, to the human right to "play God" with genetic material, to the meaning of free will in relation to genetically influ­ enced behaviors. In the more "practical" arena are studies of economic, safety, and environmental issues in relation to the release of genetical­ ly modified organisms (GMOs) at a time when public mistrust of science is increas­ ing, particularly in Europe; the commercial and legal issues associated with the patent­ ing of genetic material, procedures, and data, including international treaties and obligations as well as the right to free access to published data; and the forensic implications of DNA profiles in legal issues from paternity testing to the presumption of innocence.

It is important to appreciate that there is no pre­ sumption that the invertebrate trait is the same as a mammalian trait; rather, the fact that molecular interactions between gene products can be conserved even when they affect distinct processes allows the functional comparison of genes across species (Bier 2005). 3 Managing and Distributing Genome Data As with many areas of science and technol­ ogy, genome science has benefited greatly from advances in computing capabilities. Improved computational speed has been important, but a strong argument can be made that the growth of the internet has been even more crucial for genome scien­ tists.

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A Primer of Genome Science by Greg Gibson


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